{"id":103,"date":"2023-03-15T20:21:00","date_gmt":"2023-03-15T11:21:00","guid":{"rendered":"https:\/\/hara-heart.com\/blog\/?p=103"},"modified":"2023-01-29T13:32:49","modified_gmt":"2023-01-29T04:32:49","slug":"%e3%82%a8%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%82%bf%e3%82%a8%e3%83%b3%e9%85%b8%ef%bc%88epa%ef%bc%89","status":"publish","type":"post","link":"https:\/\/hara-heart.com\/blog\/archives\/103\/","title":{"rendered":"\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09"},"content":{"rendered":"\n<pre class=\"wp-block-preformatted\">\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u3044\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u4e00\u822c\u8ca9\u58f2\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u304c\u3001\u533b\u5b66\u7684\u306b\u3082\n\n<mark style=\"background-color:#fffcbf\" class=\"has-inline-color\">\u3000\u30fb\u4e2d\u6027\u8102\u80aa\u3092\u4e0b\u3052\u308b\n\u3000\u30fb\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8efd\u6e1b\u3059\u308b\n\u3000\u30fb\u8840\u6db2\u3092\u3055\u3089\u3055\u3089\u306b\u3059\u308b<\/mark>\n\n\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001<a href=\"https:\/\/hara-heart.com\/dyslipidemia.html\" target=\"_blank\" rel=\"noopener\" title=\"\u9ad8\u8102\u8840\u75c7\">\u9ad8\u8102\u8840\u75c7<\/a>\u306b\u5bfe\u3059\u308b\u533b\u85ac\u54c1\u3068\u3057\u3066\u8a8d\u53ef\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\n\n\n1970\u5e74\u4ee3\u306b\u884c\u308f\u308c\u305f\u75ab\u5b66\u8abf\u67fb\u306b\u3066\u3001\u9b5a\u3084\u30a2\u30b6\u30e9\u30b7\u304b\u3089\u4e3b\u306b\u8102\u80aa\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u30b0\u30ea\u30fc\u30f3\u30e9\u30f3\u30c9\u306e\u30a4\u30cc\u30a4\u30c3\u30c8\u304c\u3001<a href=\"https:\/\/hara-heart.com\/myocardial-infarction.html\" target=\"_blank\" rel=\"noopener\" title=\"\u5fc3\u7b4b\u6897\u585e\u30fb\u72ed\u5fc3\u75c7\">\u5fc3\u7b4b\u6897\u585e\u30fb\u72ed\u5fc3\u75c7<\/a>\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u6975\u3081\u3066\u5c11\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002(1) \n\u9b5a\u3084\u30a2\u30b6\u30e9\u30b7\u306e\u8102\u80aa\u306b\u306fEPA\u304c\u591a\u304f\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u30b0\u30ea\u30fc\u30f3\u30e9\u30f3\u30c9\u306e\u4eba\u3005\u306e\u8840\u4e2d\u306b\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u3067\u3042\u308bEPA\u304c\u9ad8\u6fc3\u5ea6\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u3001EPA\u304c\u5fc3\u81d3\u75c5\u3092\u4e88\u9632\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002\n\nEPA\u304c\u5b9f\u969b\u306b<a href=\"https:\/\/hara-heart.com\/myocardial-infarction.html\" target=\"_blank\" rel=\"noopener\" title=\"\u5fc3\u7b4b\u6897\u585e\u30fb\u72ed\u5fc3\u75c7\">\u5fc3\u7b4b\u6897\u585e\u30fb\u72ed\u5fc3\u75c7<\/a>\u306a\u3069\u306e\u51a0\u52d5\u8108\u75be\u60a3\u3092\u4e88\u9632\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u306e\u304c\u3001\u65e5\u672c\u3067\u884c\u308f\u308c\u305fJELIS\u8a66\u9a13\u306b\u306a\u308a\u307e\u3059\u3002(2)  \n\u3053\u306e\u8a66\u9a13\u3067\u306f\u300118,645\u4eba\u3092\u5bfe\u8c61\u306bEPA (1,800 mg\/\u65e5)\u3092\u5185\u670d\u3059\u308b\u4eba\u3068\u3001\u5185\u670d\u3057\u306a\u3044\u4eba\u3068\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u632f\u308a\u5206\u3051\u3001EPA\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3057\u3066\u304a\u308a\u3001\u51a0\u52d5\u8108\u75be\u60a3\u3092\u7d0420%\u4e88\u9632\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\n\u307e\u305f\u3001\u8133\u5352\u4e2d\u306e\u518d\u767a\u309220%\u6e1b\u3089\u3059\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002(3)\n\n\u6700\u8fd1\u3067\u306f\u3001EPA 4,000 mg\/\u65e5\u3068\u9ad8\u7528\u91cf\u3092\u6295\u4e0e\u3057\u305f\u5834\u5408\u306e\u52b9\u679c\u304c\u3001REDUCE-IT\u8a66\u9a13(4)\u3001EVAPORATE\u8a66\u9a13(5)\u306a\u3069\u3067\u8a73\u7d30\u306b\u691c\u8a3c\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\n\u7279\u306b\u3001REDUCE-IT\u8a66\u9a13\u3067\u306f\u7d0425%\u3001\u51a0\u52d5\u8108\u75be\u60a3\u3092\u4e88\u9632\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/pre>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/01\/502452-1024x833.jpg\" alt=\"\" class=\"wp-image-104\" width=\"220\" height=\"178\" srcset=\"https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/01\/502452-1024x833.jpg 1024w, https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/01\/502452-300x244.jpg 300w, https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/01\/502452-768x625.jpg 768w, https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/01\/502452.jpg 1475w\" sizes=\"auto, (max-width: 220px) 100vw, 220px\" \/><\/figure>\n\n\n\n<pre class=\"wp-block-preformatted\">EPA\u306f\u3044\u308f\u3057\u30fb\u3055\u3070\u30fb\u3042\u3058\u306a\u3069\u306e\u9752\u9b5a\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u666e\u6bb5\u306e\u98df\u751f\u6d3b\u3067\u5341\u5206\u3068\u3044\u3046\u65b9\u3082\u3044\u308b\u304b\u3068\u601d\u3044\u307e\u3059\u3002\n\u4e00\u65b9\u3067\u3001\u98df\u751f\u6d3b\u306b\u3088\u3063\u3066\u306f\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5185\u670d\u3057\u3066\u3044\u3066\u3082\u3001\u52b9\u679c\u3092\u5f97\u308b\u306b\u306f\u7528\u91cf\u304c\u5341\u5206\u3067\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff08\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u306eEPA\u306e\u7528\u91cf\u306f180\u301c1,250 mg\/\u65e5\u7a0b\u5ea6\u3068\u306a\u308a\u307e\u3059\uff09\u3002\n\n\u5f53\u9662\u3067\u306f\u3001<a href=\"https:\/\/hara-heart.com\/dyslipidemia.html\" title=\"\u9ad8\u8102\u8840\u75c7\">\u9ad8\u8102\u8840\u75c7<\/a>\u306e\u65b9\u306b\u3001\u52d5\u8108\u786c\u5316\u306e\u7a0b\u5ea6\u3084\u75c5\u72b6\u306b\u5fdc\u3058\u3066\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u88fd\u5264\u306e\u51e6\u65b9\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\n\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5185\u670d\u3057\u3066\u3044\u308b\u3042\u308b\u3044\u306f\u59cb\u3081\u3088\u3046\u3068\u601d\u3063\u3066\u3044\u308b\u65b9\u3067\u3082\u3001\u6c17\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308c\u3070\u3001\u305c\u3072\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\n\n\n\u53c2\u8003\u6587\u732e\n\n1.\tDyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978;2:117-9.\n2.\tYokoyama M, Origasa H, Matsuzaki M et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369:1090-8.\n3.\tTanaka K, Ishikawa Y, Yokoyama M et al. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial. Stroke 2008;39:2052-8.\n4.\tBhatt DL, Steg PG, Miller M et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med 2019;380:11-22.\n5.\tBudoff MJ, Bhatt DL, Kinninger A et al. Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial. Eur Heart J 2020;41:3925-3932.<\/pre>\n","protected":false},"excerpt":{"rendered":"<p>\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u3044\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u4e00\u822c\u8ca9\u58f2\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u304c\u3001\u533b\u5b66\u7684\u306b\u3082 \u3000\u30fb\u4e2d\u6027\u8102\u80aa\u3092\u4e0b\u3052\u308b \u3000\u30fb\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8efd\u6e1b\u3059\u308b \u3000\u30fb\u8840\u6db2\u3092\u3055\u3089\u3055\u3089\u306b\u3059\u308b \u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u9ad8\u8102\u8840\u75c7\u306b\u5bfe\u3059 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":{"0":"post-103","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-3"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/comments?post=103"}],"version-history":[{"count":6,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/103\/revisions"}],"predecessor-version":[{"id":156,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/103\/revisions\/156"}],"wp:attachment":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/media?parent=103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/categories?post=103"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/tags?post=103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}