{"id":221,"date":"2023-04-10T01:21:03","date_gmt":"2023-04-09T16:21:03","guid":{"rendered":"https:\/\/hara-heart.com\/blog\/?p=221"},"modified":"2023-04-10T01:21:04","modified_gmt":"2023-04-09T16:21:04","slug":"%e6%9c%80%e6%96%b0%e3%81%ae%e7%b3%96%e5%b0%bf%e7%97%85%e6%b2%bb%e7%99%82-%e7%b3%96%e5%b0%bf%e7%97%85%e6%b2%bb%e7%99%82%e3%81%8c%e5%bf%83%e8%87%93%e7%97%85%e3%83%bb%e8%85%8e%e8%87%93%e7%97%85","status":"publish","type":"post","link":"https:\/\/hara-heart.com\/blog\/archives\/221\/","title":{"rendered":"\u6700\u65b0\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642 &#8211; \u7cd6\u5c3f\u75c5\u6cbb\u7642\u304c\u5fc3\u81d3\u75c5\u30fb\u814e\u81d3\u75c5\u3092\u4e88\u9632\u3059\u308b"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2023\/04\/f4e0cc019d1e6d50f1eebc4289222f61-1-1024x877.jpg\" alt=\"\" class=\"wp-image-229\" width=\"278\" height=\"238\" 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style=\"background-color:#fffcbf\" class=\"has-inline-color\">\u30fb\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\n\u30fbSGLT2\u963b\u5bb3\u85ac\n\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u6ce8\u5c04\u3001\u7d4c\u53e3\u3068\u3082\u306b\u3042\u308a\uff09<\/mark>\n\n\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u85ac\u306f\u4e3b\u306b\u51e6\u65b9\u3059\u308b\u306e\u306f\u3001\u4e0b\u8a18\u3067\u7d39\u4ecb\u3059\u308b\u5fc3\u81d3\u75c5\u3092\u4e88\u9632\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\n\n<\/pre>\n\n\n\n<strong><mark style=\"background-color:#f3faff;color:#000088\" class=\"has-inline-color\">\n\u5f53\u9662\u3067\u3088\u304f\u51e6\u65b9\u3059\u308b\u5185\u670d\u3068\u305d\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark><\/strong><Br>\n<Br>\n<strong><mark style=\"background-color:#f3faff;color:#000088\" 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class=\"has-inline-color\">\u6b7b\u4ea1\u3092\u3078\u3089\u3059\u4e8b\u304c\u3067\u304d\u308b<\/mark>\u3068\u3044\u3046\u306e\u306f\u85ac\u3092\u9078\u629e\u80a2\u3059\u308b\u4e0a\u3067\u5927\u304d\u306a\u610f\u7fa9\u3092\u3082\u3064\u3068\u3044\u3048\u307e\u3059\u3002<Br>\n<mark style=\"background-color:#fffcbf\" class=\"has-inline-color\">\u975e\u5e38\u306b\u5b89\u4fa1\uff08\uff13\u5272\u8ca0\u62c5\u3067\uff11\u9320\uff13\u5186\u7a0b\u5ea6\uff09<\/mark>\u3068\u3044\u3046\u306e\u3082\u9b45\u529b\u3067\u3059\u3002<Br>\n<Br>\n<mark style=\"background-color:#f3faff;color:#000088\" class=\"has-inline-color\">\n\u6ce8\u610f\u70b9<\/mark><Br>\n\u814e\u6a5f\u80fd\u304c\u60aa\u3044\u65b9\u3084\u3001CT\u691c\u67fb\u306a\u3069\u3067\u9020\u5f71\u5264\u3092\u4f7f\u7528\u3059\u308b\u969b\u306f\u3001\u4e73\u9178\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<Br>\n<Br>\n<Br>\n\n<strong><mark style=\"background-color:#f3faff;color:#000088\" class=\"has-inline-color\">\n\u2605SGLT2\u963b\u5bb3\u85ac<\/mark><\/strong><Br>\n<Br>\n2022\u5e74\u306b\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u304b\u3089\u516c\u8868\u3055\u308c\u305f\u85ac\u7269\u6cbb\u7642\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u304a\u3044\u3066\u3001<mark style=\"background-color:#fffcbf\" class=\"has-inline-color\">\u6162\u6027\u814e\u81d3\u75c5\u3001\u5fc3\u4e0d\u5168\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u4ed8\u52a0\u7684\u306a\u52b9\u679c\u3092\u671f\u5f85\u3057\u3066\u3001SGLT2\u963b\u5bb3\u85ac\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/mark>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<Br>\n<Br>\n<mark style=\"background-color:#f3faff;color:#000088\" class=\"has-inline-color\">\n\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark><Br>\nEugene 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58\u8a66\u9a13(5)\u3001CANVAS\u8a66\u9a13(6)\u306b\u304a\u3044\u3066\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3001\u30ab\u30ca\u30b0\u30eb\u304c\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u4e0d\u5168\u30922-\uff13\u5272\u3078\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u305f\u3053\u3068\u306b\u8a00\u53ca\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002<Br>\n<Br>\n\u5fc3\u4e0d\u5168\u3092\u5408\u4f75\u3057\u305f\u60a3\u8005\u306b\u3066\u304a\u3044\u3066\u306f\u3001EMPEROR-Reduced\u8a66\u9a13(7)\u3001EMPEROR-Preserved\u8a66\u9a13(8)\u3001DAPA-HF\u8a66\u9a13(9)\u3001DELIVER\u8a66\u9a13(10)\u304c\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5fc3\u4e0d\u5168\u306e\u518d\u767a\u3092\u7d04\uff13\u5272\u3078\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6700\u65b0\u306e\u5fc3\u4e0d\u5168\u6cbb\u7642\u3000\u300c\u30d5\u30a1\u30f3\u30bf\u30b9\u30c6\u30a3\u30c3\u30af\uff14\u300d\u306e\uff11\u3064\u3068\u3057\u3066SGLT2\u963b\u5bb3\u85ac\u306e\u5185\u670d\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<Br>\n<Br>\n\u3055\u3089\u306b\u3001\u6162\u6027\u814e\u4e0d\u5168\u60a3\u8005\u306b\u3066\u304a\u3044\u3066\u3001EMPA-KIDNEY\u8a66\u9a13(11)\u3001DAPA-CKD\u8a66\u9a13(12)\u3001CREDENCE\u8a66\u9a13(13)\u306b\u304a\u3044\u3066\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3001\u30ab\u30ca\u30b0\u30eb\u304c\u814e\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002<Br>\n<Br>\n<mark 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class=\"wp-block-preformatted\">1.\tEffect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854-65.\n2.\tHolman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-89.\n3.\tBraunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med 2022;386:2024-2034.\n4.\tZinman B, Wanner C, Lachin JM et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 2015;373:2117-28.\n5.\tWiviott SD, Raz I, Bonaca MP et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2019;380:347-357.\n6.\tNeal B, Perkovic V, Mahaffey KW et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med 2017;377:644-657.\n7.\tPacker M, Anker SD, Butler J et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med 2020;383:1413-1424.\n8.\tAnker SD, Butler J, Filippatos G et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med 2021;385:1451-1461.\n9.\tMcMurray JJV, Solomon SD, Inzucchi SE et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med 2019;381:1995-2008.\n10.\tSolomon SD, McMurray JJV, Claggett B et al. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med 2022;387:1089-1098.\n11.\tHerrington WG, Staplin N, Wanner C et al. Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med 2023;388:117-127.\n12.\tHeerspink HJL, Stef\u00e1nsson BV, Correa-Rotter R et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med 2020;383:1436-1446.\n13.\tPerkovic V, Jardine MJ, Neal B et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med 2019;380:2295-2306.\n14.\tMaruthur NM, Tseng E, Hutfless S et al. Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis. Ann Intern Med 2016;164:740-51.\n15.\tMarso SP, Daniels GH, Brown-Frandsen K et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016;375:311-22.\n16.\tMarso SP, Bain SC, Consoli A et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2016;375:1834-1844.\n17.\tHusain M, Birkenfeld AL, Donsmark M et al. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2019;381:841-851.\n18.\tMann JFE, \u00d8rsted DD, Brown-Frandsen K et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017;377:839-848.\n19.\tYamada Y, Katagiri H, Hamamoto Y et al. Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2\/3a, randomised, controlled trial. Lancet Diabetes Endocrinol 2020;8:377-391.\n20.\tYabe D, Nakamura J, Kaneto H et al. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial. Lancet Diabetes Endocrinol 2020;8:392-406.\n\n<\/pre>\n","protected":false},"excerpt":{"rendered":"<p>\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3059\u3044\u81d3\u306e\u7d30\u80de\u306b\u969c\u5bb3\u304c\u3042\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u51fa\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u539f\u56e0\u306e\uff11\u578b\u7cd6\u5c3f\u75c5\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u88dc\u3046\u6cbb\u7642\u304c\u57fa\u672c\u3068\u306a\u308a\u307e\u3059\u3002 \u4e00\u65b9\u3067\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3084\u3001\u904e\u98df\u3001\u904b\u52d5\u4e0d\u8db3\u3001\u52a0\u9f62\u306a\u3069\u306b\u3088\u308b\u4e3b\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u4f5c [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,6],"tags":[],"class_list":["post-221","post","type-post","status-publish","format-standard","category-3","category-6"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - 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