{"id":221,"date":"2023-04-10T01:21:03","date_gmt":"2023-04-09T16:21:03","guid":{"rendered":"https:\/\/hara-heart.com\/blog\/?p=221"},"modified":"2023-04-10T01:21:04","modified_gmt":"2023-04-09T16:21:04","slug":"%e6%9c%80%e6%96%b0%e3%81%ae%e7%b3%96%e5%b0%bf%e7%97%85%e6%b2%bb%e7%99%82-%e7%b3%96%e5%b0%bf%e7%97%85%e6%b2%bb%e7%99%82%e3%81%8c%e5%bf%83%e8%87%93%e7%97%85%e3%83%bb%e8%85%8e%e8%87%93%e7%97%85","status":"publish","type":"post","link":"https:\/\/hara-heart.com\/blog\/archives\/221\/","title":{"rendered":"\u6700\u65b0\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642 – \u7cd6\u5c3f\u75c5\u6cbb\u7642\u304c\u5fc3\u81d3\u75c5\u30fb\u814e\u81d3\u75c5\u3092\u4e88\u9632\u3059\u308b"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n
\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3059\u3044\u81d3\u306e\u7d30\u80de\u306b\u969c\u5bb3\u304c\u3042\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u51fa\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u539f\u56e0\u306e\uff11\u578b\u7cd6\u5c3f\u75c5\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u88dc\u3046\u6cbb\u7642\u304c\u57fa\u672c\u3068\u306a\u308a\u307e\u3059\u3002\n\n\u4e00\u65b9\u3067\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3084\u3001\u904e\u98df\u3001\u904b\u52d5\u4e0d\u8db3\u3001\u52a0\u9f62\u306a\u3069\u306b\u3088\u308b\u4e3b\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u4f5c\u7528\u3057\u306b\u304f\u304f\u306a\u3063\u3066\u3044\u308b\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff09\u3053\u3068\u304c\u539f\u56e0\u3068\u306a\u308b\uff12\u578b\u7cd6\u5c3f\u75c5\u3067\u306f\u3001\u98df\u4e8b\u30fb\u904b\u52d5\u7642\u6cd5\u306b\u52a0\u3048\u3066\u3001\u5185\u670d\u6cbb\u7642\u30fb\u6ce8\u5c04\u6cbb\u7642\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\n\n\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u85ac\u306b\u306f\u3001\n\t\n\u30fb\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\uff08SU\u85ac\uff09\n\u30fb\u901f\u52b9\u578b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u85ac\uff08\u30b0\u30ea\u30cb\u30c9\u85ac\uff09\n\u30fb\u03b1-\u30b0\u30eb\u30b3\u30b7\u30c0\u30fc\u30bc\u963b\u5bb3\u85ac\n\u30fb\u30c1\u30a2\u30be\u30ea\u30b8\u30f3\u85ac\n\u30fb\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\n\u30fb\u30a4\u30e1\u30b0\u30ea\u30df\u30f3\n\u30fbDPP-\uff14\u963b\u5bb3\u85ac\n\u30fbSGLT2\u963b\u5bb3\u85ac\n\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u6ce8\u5c04\u3001\u7d4c\u53e3\u3068\u3082\u306b\u3042\u308a\uff09\n\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\n\n\u3068\u591a\u304f\u306e\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5f53\u9662\u3067\u3088\u304f\u51e6\u65b9\u3059\u308b\u306e\u306f\u3001\n\n\u30fb\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\n\u30fbSGLT2\u963b\u5bb3\u85ac\n\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u6ce8\u5c04\u3001\u7d4c\u53e3\u3068\u3082\u306b\u3042\u308a\uff09<\/mark>\n\n\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u85ac\u306f\u4e3b\u306b\u51e6\u65b9\u3059\u308b\u306e\u306f\u3001\u4e0b\u8a18\u3067\u7d39\u4ecb\u3059\u308b\u5fc3\u81d3\u75c5\u3092\u4e88\u9632\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\n\n<\/pre>\n\n\n\n\n\u5f53\u9662\u3067\u3088\u304f\u51e6\u65b9\u3059\u308b\u5185\u670d\u3068\u305d\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark><\/strong>
\n
\n\n\u2605\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\uff08\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306a\u3069\uff09<\/mark><\/strong>
\n
\n\u82f1\u56fd\u3067\u884c\u308f\u308c\u305f\u80a5\u6e80\u578b\u7cd6\u5c3f\u75c5\u306e\u524d\u5411\u304d\u7814\u7a76UKPDS34\u3067\u306f\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3<\/mark>\u304cSU\u85ac\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u88fd\u5264\u3088\u308a\u3082\u3001\u8133\u5352\u4e2d\u3084\u6b7b\u4ea1\u3092\u6709\u610f\u306b\u6e1b\u3089\u3059<\/mark>\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002(1)
\n\u3055\u3089\u306b10\u5e74\u5f8c\u307e\u3067\u8ffd\u8de1\u8abf\u67fb\u3092\u884c\u3063\u305fUKPDS80\u8a66\u9a13\u306b\u3066\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u52b9\u679c\u304c10\u5e74\u7d4c\u904e\u3057\u3066\u3082\u6301\u7d9a\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002(2)
\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\u306e\u8a73\u7d30\u306a\u6a5f\u5e8f\u306f\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u90e8\u5206\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u6b7b\u4ea1\u3092\u3078\u3089\u3059\u4e8b\u304c\u3067\u304d\u308b<\/mark>\u3068\u3044\u3046\u306e\u306f\u85ac\u3092\u9078\u629e\u80a2\u3059\u308b\u4e0a\u3067\u5927\u304d\u306a\u610f\u7fa9\u3092\u3082\u3064\u3068\u3044\u3048\u307e\u3059\u3002
\n\u975e\u5e38\u306b\u5b89\u4fa1\uff08\uff13\u5272\u8ca0\u62c5\u3067\uff11\u9320\uff13\u5186\u7a0b\u5ea6\uff09<\/mark>\u3068\u3044\u3046\u306e\u3082\u9b45\u529b\u3067\u3059\u3002
\n
\n\n\u6ce8\u610f\u70b9<\/mark>
\n\u814e\u6a5f\u80fd\u304c\u60aa\u3044\u65b9\u3084\u3001CT\u691c\u67fb\u306a\u3069\u3067\u9020\u5f71\u5264\u3092\u4f7f\u7528\u3059\u308b\u969b\u306f\u3001\u4e73\u9178\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002
\n
\n
\n\n\n\u2605SGLT2\u963b\u5bb3\u85ac<\/mark><\/strong>
\n
\n2022\u5e74\u306b\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u304b\u3089\u516c\u8868\u3055\u308c\u305f\u85ac\u7269\u6cbb\u7642\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u304a\u3044\u3066\u3001\u6162\u6027\u814e\u81d3\u75c5\u3001\u5fc3\u4e0d\u5168\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u4ed8\u52a0\u7684\u306a\u52b9\u679c\u3092\u671f\u5f85\u3057\u3066\u3001SGLT2\u963b\u5bb3\u85ac\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/mark>\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n
\n\n\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark>
\nEugene Braunwald\u5148\u751f\u306f\u3001\u5faa\u74b0\u5668\u696d\u754c\u306e\u751f\u304d\u308b\u30ec\u30b8\u30a7\u30f3\u30c9\u3067\u3042\u308a\u300190\u6b73\u3092\u8d85\u3048\u3066\u306a\u304a\u3001\u9662\u9577\u304c\u7559\u5b66\u3057\u3066\u3044\u305f\u3068\u304d\u306b\u884c\u3063\u3066\u3044\u305f\u56fd\u969b\u5171\u540c\u7814\u7a76\u306eWEB\u4f1a\u8b70\u306b\u3082\u81ea\u3089\u53c2\u52a0\u3055\u308c\u308b\u307b\u3069\u306e\u30a2\u30b0\u30ec\u30c3\u30b7\u30d6\u306a\u5148\u751f\u3002
\n\u305d\u3093\u306a\u3001\u73fe\u572893\u6b73\u3068\u306a\u308bEugene Braunwald\u5148\u751f\u306e\u7dcf\u8aac\u3067\u3082\u3001SGLT2\u963b\u5bb3\u85ac\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307e\u3068\u3081\u3089\u308c\u3066\u304a\u308a\u307e\u3059\u3002(3)
\n
\n\u3053\u306e\u4e2d\u3067\u3001EMPA-REG OUTCOME\u8a66\u9a13(4)\u3001DECLARE\u2013TIMI 58\u8a66\u9a13(5)\u3001CANVAS\u8a66\u9a13(6)\u306b\u304a\u3044\u3066\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3001\u30ab\u30ca\u30b0\u30eb\u304c\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u4e0d\u5168\u30922-\uff13\u5272\u3078\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u305f\u3053\u3068\u306b\u8a00\u53ca\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002
\n
\n\u5fc3\u4e0d\u5168\u3092\u5408\u4f75\u3057\u305f\u60a3\u8005\u306b\u3066\u304a\u3044\u3066\u306f\u3001EMPEROR-Reduced\u8a66\u9a13(7)\u3001EMPEROR-Preserved\u8a66\u9a13(8)\u3001DAPA-HF\u8a66\u9a13(9)\u3001DELIVER\u8a66\u9a13(10)\u304c\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5fc3\u4e0d\u5168\u306e\u518d\u767a\u3092\u7d04\uff13\u5272\u3078\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6700\u65b0\u306e\u5fc3\u4e0d\u5168\u6cbb\u7642\u3000\u300c\u30d5\u30a1\u30f3\u30bf\u30b9\u30c6\u30a3\u30c3\u30af\uff14\u300d\u306e\uff11\u3064\u3068\u3057\u3066SGLT2\u963b\u5bb3\u85ac\u306e\u5185\u670d\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n
\n\u3055\u3089\u306b\u3001\u6162\u6027\u814e\u4e0d\u5168\u60a3\u8005\u306b\u3066\u304a\u3044\u3066\u3001EMPA-KIDNEY\u8a66\u9a13(11)\u3001DAPA-CKD\u8a66\u9a13(12)\u3001CREDENCE\u8a66\u9a13(13)\u306b\u304a\u3044\u3066\u3001\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u3001\u30ab\u30ca\u30b0\u30eb\u304c\u814e\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002
\n
\n\n\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c<\/mark>
\nSGLT2 \u963b\u5bb3\u85ac\u306f\u7cd6\u8cea\u3092\u4f53\u5185\u306b\u8caf\u8535\u3057\u306a\u3044\u305f\u30812kg\u7a0b\u5ea6\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u3001\u80a5\u6e80\u306e\u5834\u5408\u306b\u306f\u7279\u306b\u8003\u616e\u3055\u308c\u307e\u3059\u3002(14)
\n
\n
\n\n\u2605GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u6ce8\u5c04\u3001\u7d4c\u53e3\u3068\u3082\u306b\u3042\u308a\uff09<\/mark><\/strong>
\n
\n2022\u5e74\u306b\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u304b\u3089\u516c\u8868\u3055\u308c\u305f\u85ac\u7269\u6cbb\u7642\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u304a\u3044\u3066\u3001\u6162\u6027\u814e\u81d3\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u4ed8\u52a0\u7684\u306a\u52b9\u679c\u3092\u671f\u5f85\u3057\u3066\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/mark>\n\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n
\n\n\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark>
\n\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u30442 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001LEADER\u8a66\u9a13\u3067\u306f\u30d3\u30af\u30c8\u30fc\u30b6\uff08\u6ce8\u5c04\u88fd\u5264\uff09\u304c\u3001SUSTAIN-6\u8a66\u9a13\u3067\u306f\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\uff08\u6ce8\u5c04\u88fd\u5264\uff09\u304c\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u5927\u304d\u306a\u30a4\u30f3\u30d1\u30af\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002(15,16)
\n\u4e00\u65b9\u3067\u3001\u6ce8\u5c04\u88fd\u5264\u3067\u3042\u308b\u3068\u3044\u3046\u70b9\u304c\u3001\u60a3\u8005\u3055\u3093\u304c\u958b\u59cb\u3059\u308b\u4e0a\u3067\u306e\u591a\u5c11\u306e\u30cf\u30fc\u30c9\u30eb\u3068\u306a\u308b\u3053\u3068\u3082\u4e8b\u5b9f\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5f8c\u3001PIONEER-6\u8a66\u9a13\u306b\u3066\u30ea\u30d9\u30eb\u30b5\u30b9\uff08\u5185\u670d\u85ac\uff09\u3082\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002(17)
\n\u307e\u305f\u3001LEADER\u8a66\u9a13\u3001SUSTAIN-6\u8a66\u9a13\u306b\u3066\u304a\u3044\u3066\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u814e\u81d3\u3092\u4fdd\u8b77\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002(16,18)
\n
\n\n\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c<\/mark>
\nGLP-1\u306b\u306f\u6e80\u8179\u4e2d\u67a2\u306b\u4f5c\u7528\u3057\u3001\u98df\u6b32\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002
\n\u307e\u305f\u3001\u8910\u8272\u8102\u80aa\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001\u8102\u80aa\u306e\u5206\u89e3\u30fb\u71c3\u713c\u3082\u4fc3\u3057\u307e\u3059\u3002
\n\u3053\u308c\u3089\u306e\u76f8\u4e57\u7684\u306a\u52b9\u679c\u306b\u3066\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002
\n\u65e5\u672c\u4eba\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3057\u3066\u884c\u308f\u308c\u305f\u81e8\u5e8a\u8a66\u9a13PIONEER 9, 10\u3067\u306f\u30012\u301c3kg\u306e\u6e1b\u91cf\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(19,20)
\n\u7c73\u56fd\u3001EU\u8af8\u56fd\u3067\u306f\u80a5\u6e80\u75c7\u306b\u5bfe\u3057\u3066\u3059\u3067\u306b\u4f7f\u7528<\/mark>\u3055\u308c\u3066\u304a\u308a\u3001\u65e5\u672c\u3067\u30822023\u5e743\u6708\u306b\u30a6\u30b4\u30fc\u30d3\uff08\u6ce8\u5c04\u85ac\uff09\u304c\u80a5\u6e80\u75c7\u6cbb\u7642\u5264\u3068\u3057\u3066\u306e\u533b\u85ac\u54c1\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u3001\u4eca\u5f8c\u3001\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u898b\u8fbc\u307f\u3067\u3059\u3002
\n
\n\n\u88fd\u5264\u306e\u7279\u5fb4<\/mark>
\nGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u4ee5\u524d\u306f\u3001\u6ce8\u5c04\u88fd\u5264\u306e\u307f\u3067\u3057\u305f\u304c\u30012021\u5e74\u304b\u3089\u5185\u670d\u85ac\u3068\u3057\u3066\u30ea\u30d9\u30eb\u30b5\u30b9\u304c\u767b\u5834\u3044\u305f\u3057\u307e\u3057\u305f\u3002
\n\u305f\u3060\u3057\u3001\u5185\u670d\u85ac\u306e\u30ea\u30d9\u30eb\u30b5\u30b9\u306f\u3001\u80c3\u306e\u4e2d\u306b\u98df\u3079\u7269\u304c\u3042\u308b\u3068\u3001\u6709\u52b9\u6210\u5206\u304c\u5438\u53ce\u3055\u308c\u305a\u3001\u672c\u6765\u306e\u52b9\u679c\u304c\u767a\u63ee\u3055\u308c\u306a\u3044\u305f\u3081\u3001
\n\n\u30fb1\u65e51\u56de\u3001\u7a7a\u8179\u6642\uff08\u671d\u98df\u524d\uff09\u306b\u3001\u30b3\u30c3\u30d7\u534a\u5206\uff08120mL\u4ee5\u4e0b\uff09\u306e\u6c34\u3068\u3068\u3082\u306b\u5185\u670d
\n\u30fb\u98f2\u98df\u306f\u5185\u670d\u5f8c30\u5206\u4ee5\u964d\u3068\u3059\u308b
\n\u3068\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002
\n\u3061\u306a\u307f\u306b\u3001\u30ea\u30d9\u30eb\u30b5\u30b9\u306b\u306f3mg\u30017mg\u300114mg\u30683\u7a2e\u985e\u304c\u3042\u308a\u3001\u5897\u91cf\u3059\u308b\u307b\u3069\u52b9\u679c\u304c\u9ad8\u3044\u3067\u3059\u3002
\n\u307e\u305a\u306f\u30011\u65e51\u56de3mg\u304b\u3089\u958b\u59cb\u3057\u30014\u9031\u9593\u4ee5\u4e0a\u7d4c\u904e\u3057\u305f\u5f8c\u306b\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u30667mg\u306b\u5897\u91cf\u3057\u307e\u3059\u3002
\n\u307e\u305f\u30017mg\u30924\u9031\u9593\u4ee5\u4e0a\u6295\u4e0e\u3057\u3066\u3082\u52b9\u679c\u304c\u5341\u5206\u3067\u306a\u3044\u5834\u5408\u306f\u300114mg\u306b\u5897\u91cf\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002
\n\u4ee3\u8868\u7684\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u3001\u4fbf\u79d8\u3001\u4e0b\u75e2\u3001\u304a\u8179\u304c\u5f35\u308b\u3001\u3080\u304b\u3080\u304b\u3059\u308b\u3001\u3068\u3044\u3063\u305f\u80c3\u8178\u75c7\u72b6\u304c\u3042\u308b\u305f\u3081\u3001\u6ce8\u610f\u6df1\u304f\u307f\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002
\n
\n
\n\n\u307e\u3068\u3081<\/mark><\/strong>
\n
\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\u3001SGLT2\u963b\u5bb3\u85ac\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3001\u3044\u305a\u308c\u3082\u3001\u4f4e\u8840\u7cd6\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u3001\u5408\u4f75\u75c7\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089\u3082\u512a\u308c\u305f\u7cd6\u5c3f\u75c5\u85ac<\/mark>\u3068\u3044\u3048\u307e\u3059\u3002
\n\u5f53\u9662\u3067\u306f\u3001\u5404\u3005\u306e\u60a3\u8005\u3055\u3093\u306e\u62b1\u3048\u3066\u3044\u308b\u75be\u60a3\u3084\u751f\u6d3b\u7fd2\u6163\u3092\u8e0f\u307e\u3048\u3066\u5185\u670d\u85ac\u3092\u691c\u8a0e\u3044\u305f\u3057\u307e\u3059\u3002
\n
\n
\n\n\u53c2\u8003\u6587\u732e<\/mark><\/strong>
\n
\n\n\n\n
1.\tEffect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854-65.\n2.\tHolman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-89.\n3.\tBraunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med 2022;386:2024-2034.\n4.\tZinman B, Wanner C, Lachin JM et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 2015;373:2117-28.\n5.\tWiviott SD, Raz I, Bonaca MP et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2019;380:347-357.\n6.\tNeal B, Perkovic V, Mahaffey KW et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med 2017;377:644-657.\n7.\tPacker M, Anker SD, Butler J et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med 2020;383:1413-1424.\n8.\tAnker SD, Butler J, Filippatos G et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med 2021;385:1451-1461.\n9.\tMcMurray JJV, Solomon SD, Inzucchi SE et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med 2019;381:1995-2008.\n10.\tSolomon SD, McMurray JJV, Claggett B et al. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med 2022;387:1089-1098.\n11.\tHerrington WG, Staplin N, Wanner C et al. Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med 2023;388:117-127.\n12.\tHeerspink HJL, Stef\u00e1nsson BV, Correa-Rotter R et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med 2020;383:1436-1446.\n13.\tPerkovic V, Jardine MJ, Neal B et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med 2019;380:2295-2306.\n14.\tMaruthur NM, Tseng E, Hutfless S et al. Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis. Ann Intern Med 2016;164:740-51.\n15.\tMarso SP, Daniels GH, Brown-Frandsen K et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016;375:311-22.\n16.\tMarso SP, Bain SC, Consoli A et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2016;375:1834-1844.\n17.\tHusain M, Birkenfeld AL, Donsmark M et al. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2019;381:841-851.\n18.\tMann JFE, \u00d8rsted DD, Brown-Frandsen K et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017;377:839-848.\n19.\tYamada Y, Katagiri H, Hamamoto Y et al. Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2\/3a, randomised, controlled trial. Lancet Diabetes Endocrinol 2020;8:377-391.\n20.\tYabe D, Nakamura J, Kaneto H et al. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial. Lancet Diabetes Endocrinol 2020;8:392-406.\n\n<\/pre>\n","protected":false},"excerpt":{"rendered":"
\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3059\u3044\u81d3\u306e\u7d30\u80de\u306b\u969c\u5bb3\u304c\u3042\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u51fa\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u539f\u56e0\u306e\uff11\u578b\u7cd6\u5c3f\u75c5\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u88dc\u3046\u6cbb\u7642\u304c\u57fa\u672c\u3068\u306a\u308a\u307e\u3059\u3002 \u4e00\u65b9\u3067\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3084\u3001\u904e\u98df\u3001\u904b\u52d5\u4e0d\u8db3\u3001\u52a0\u9f62\u306a\u3069\u306b\u3088\u308b\u4e3b\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u4f5c […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,6],"tags":[],"class_list":{"0":"post-221","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-3","7":"category-6"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/comments?post=221"}],"version-history":[{"count":7,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/221\/revisions"}],"predecessor-version":[{"id":230,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/posts\/221\/revisions\/230"}],"wp:attachment":[{"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/media?parent=221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/categories?post=221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hara-heart.com\/blog\/wp-json\/wp\/v2\/tags?post=221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}