{"id":604,"date":"2026-09-27T17:15:45","date_gmt":"2026-09-27T08:15:45","guid":{"rendered":"https:\/\/hara-heart.com\/blog\/?p=604"},"modified":"2026-09-27T17:15:46","modified_gmt":"2026-09-27T08:15:46","slug":"nitroglycerin-history","status":"publish","type":"post","link":"https:\/\/hara-heart.com\/blog\/archives\/604\/","title":{"rendered":"\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u3061\u3087\u3063\u3068\u610f\u5916\u306a\u6b74\u53f2 \u2015 \u30c0\u30a4\u30ca\u30de\u30a4\u30c8\u304b\u3089\u3001\u30ce\u30fc\u30d9\u30eb\u8cde\u3078 \u2015"},"content":{"rendered":"\n<div class=\"nitro-article\" lang=\"ja\" style=\"max-width:860px;margin:0 auto;color:#343b40;font-family:inherit;font-size:1em;line-height:1.95;overflow-wrap:anywhere;\">\n<!-- NITRO_HERO_START -->\n<figure class=\"nitro-hero\" style=\"margin:0 0 2em;\"><img loading=\"lazy\" alt=\"\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u3061\u3087\u3063\u3068\u610f\u5916\u306a\u6b74\u53f2\u3002\u30c0\u30a4\u30ca\u30de\u30a4\u30c8\u3001\u85ac\u74f6\u3001\u5fc3\u81d3\u3001\u5b9f\u9a13\u5668\u5177\u3001\u30e1\u30c0\u30eb\u3092\u63cf\u3044\u305f\u6c34\u5f69\u8abf\u306e\u30a4\u30e9\u30b9\u30c8\u3002\" decoding=\"async\" height=\"941\" src=\"https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2026\/09\/nitroglycerin-history-cover.webp\" style=\"display:block;width:100%;max-width:100%;height:auto;border-radius:5px;\" width=\"1672\"\/><\/figure>\n<!-- NITRO_HERO_END -->\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u3067\u306f\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068\u3044\u3046\u85ac\u3092\u4f7f\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u5faa\u74b0\u5668\u8a3a\u7642\u3067\u306f\u6614\u304b\u3089\u4f7f\u308f\u308c\u3066\u3044\u308b\u85ac\u3067\u3059\u304c\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068\u3044\u3046\u540d\u524d\u304b\u3089\u3001\u30c0\u30a4\u30ca\u30de\u30a4\u30c8\u3092\u601d\u3044\u6d6e\u304b\u3079\u308b\u65b9\u3082\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u4eca\u56de\u3001\u533b\u5b66\u8a8c <span lang=\"en\">New England Journal of Medicine<\/span>\uff08NEJM\uff09\u306b\u63b2\u8f09\u3055\u308c\u305f\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u306e\u6b74\u53f2\u3092\u3081\u3050\u308b\u6587\u7ae0\u3092\u8aad\u307f\u307e\u3057\u305f\u30022015\u5e74\u306b\u63b2\u8f09\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u666e\u6bb5\u306e\u8a3a\u7642\u3067\u3082\u4f7f\u3046\u85ac\u3067\u3059\u304c\u3001\u305d\u306e\u6b74\u53f2\u3092\u305f\u3069\u308b\u3068\u3001\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u304b\u3089\u8840\u7ba1\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u3001\u3055\u3089\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u3084\u5225\u306e\u6cbb\u7642\u85ac\u3078\u3068\u7814\u7a76\u304c\u3064\u306a\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u4eca\u56de\u306f\u3001\u3053\u306eNEJM\u306e\u6587\u7ae0\u3092\u30d9\u30fc\u30b9\u306b\u3001\u95a2\u9023\u3059\u308b\u7814\u7a76\u3082\u4ea4\u3048\u306a\u304c\u3089\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068NO\u3092\u3081\u3050\u308b\u6b74\u53f2\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<div class=\"nitro-base-reference\" id=\"nitro-ref-1\" style=\"margin:1.8em 0 2em;padding:0;background:transparent;border:0;font-family:inherit;font-size:inherit;line-height:inherit;\">\n<p style=\"margin:0 0 0.65em;font-family:inherit;font-size:inherit;line-height:inherit;font-weight:400;color:inherit;\">\u4eca\u56de\u306e\u30d9\u30fc\u30b9\u3068\u306a\u308b\u6587\u732e<\/p>\n<p style=\"margin:0 0 0.65em;font-family:inherit;font-size:inherit;line-height:inherit;font-weight:400;color:inherit;\">1. Steinhorn BS, Loscalzo J, Michel T. Nitroglycerin and Nitric Oxide \u2014 A Rondo of Themes in Cardiovascular Therapeutics. <span lang=\"en\">N Engl J Med.<\/span> 2015;373:277\u2013280. doi:10.1056\/NEJMsr1503311. <a href=\"https:\/\/doi.org\/10.1056\/NEJMsr1503311\" rel=\"noopener noreferrer\" style=\"color:#356574;text-decoration:underline;text-underline-offset:0.16em;font-family:inherit;\" target=\"_blank\">\u63b2\u8f09\u8ad6\u6587<\/a> \/ <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4836444\/\" rel=\"noopener noreferrer\" style=\"color:#356574;text-decoration:underline;text-underline-offset:0.16em;font-family:inherit;\" target=\"_blank\">\u516c\u958b\u8457\u8005\u539f\u7a3f<\/a><\/p><\/div>\n<h2 id=\"nitro-rondo\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">Rondo\uff08\u30ed\u30f3\u30c9\uff09\u2015 \u81e8\u5e8a\u3068\u7814\u7a76\u306e\u5f80\u5fa9<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30bf\u30a4\u30c8\u30eb\u306b\u3042\u308b\u300cRondo\uff08\u30ed\u30f3\u30c9\uff09\u300d\u306f\u3001\u540c\u3058\u4e3b\u984c\u304c\u7e70\u308a\u8fd4\u3057\u73fe\u308c\u3001\u305d\u306e\u9593\u306b\u7570\u306a\u308b\u65cb\u5f8b\u304c\u631f\u307e\u308b\u97f3\u697d\u5f62\u5f0f\u3067\u3059\u3002NEJM\u306e\u672c\u6587\u306f\u3001\u3053\u306e\u30ed\u30f3\u30c9\u306e\u8aac\u660e\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u8457\u8005\u3089\u306f\u3001\u60a3\u8005\u3055\u3093\u3067\u89b3\u5bdf\u3055\u308c\u305f\u73fe\u8c61\u3092\u7814\u7a76\u5ba4\u3067\u8abf\u3079\u3001\u65b0\u3057\u3044\u4ed5\u7d44\u307f\u3084\u6cbb\u7642\u3092\u898b\u3044\u3060\u3057\u3001\u305d\u308c\u304c\u518d\u3073\u60a3\u8005\u3055\u3093\u306e\u3082\u3068\u3078\u623b\u3063\u3066\u3044\u304f\u904e\u7a0b\u3092\u3001\u30ed\u30f3\u30c9\u306b\u306a\u305e\u3089\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u3055\u3089\u306b\u672c\u6587\u306e\u5192\u982d\u3067\u306f\u3001\u3053\u306e\u30ed\u30f3\u30c9\u306f\u300cE\u306e\u8abf\u300d\u3067\u9032\u3080\u3068\u8868\u73fe\u3055\u308c\u3066\u3044\u307e\u3059\u3002E\u306f <span lang=\"en\">endothelium<\/span>\u3001\u8840\u7ba1\u306e\u5185\u5074\u3092\u8986\u3046\u300c\u8840\u7ba1\u5185\u76ae\u300d\u306e\u982d\u6587\u5b57\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u4ee5\u4e0b\u3067\u306f\u3001\u81e8\u5e8a\u3067\u306e\u89b3\u5bdf\u3068\u57fa\u790e\u7814\u7a76\u304c\u884c\u304d\u6765\u3057\u3066\u304d\u305f\u7d4c\u7def\u3092\u3001\u5e74\u4ee3\u306b\u6cbf\u3063\u3066\u305f\u3069\u308a\u307e\u3059\u3002<\/p>\n<!-- NITRO_TIMELINE_START --><figure class=\"nitro-timeline\" style=\"margin:2em 0;\"><img alt=\"\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068NO\u306e\u7814\u7a76\u53f2\u30021768\u5e74\u306e\u72ed\u5fc3\u75c7\u306e\u8a18\u8f09\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u5408\u6210\u3001\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u30011980\u5e74\u306e\u5185\u76ae\u306e\u7814\u7a76\u30011987\u5e74\u306eEDRF\u3068NO\u306e\u540c\u5b9a\u30011992\u5e74\u306eeNOS\u7814\u7a76\u30011998\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u793a\u3059\u5e74\u8868\u3002\" decoding=\"async\" height=\"887\" loading=\"lazy\" src=\"https:\/\/hara-heart.com\/blog\/wp-content\/uploads\/2026\/09\/nitroglycerin-no-history-timeline.webp\" style=\"display:block;width:100%;max-width:100%;height:auto;border-radius:5px;\" width=\"1774\"\/><figcaption style=\"margin:0.8em 0 0;color:#657278;font-family:inherit;font-size:0.8em;line-height:1.8;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068NO\u3092\u3081\u3050\u308b\u7814\u7a76\u306e\u6d41\u308c<\/figcaption><\/figure><!-- NITRO_TIMELINE_END -->\n<h2 id=\"nitro-angina\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">1768\u5e74\u3001\u72ed\u5fc3\u75c7\u304c\u8a18\u8f09\u3055\u308c\u308b<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1768\u5e74\u3001\u82f1\u56fd\u306e\u533b\u5e2b\u30a6\u30a3\u30ea\u30a2\u30e0\u30fb\u30d8\u30d0\u30fc\u30c7\u30f3\uff08William Heberden\uff09\u306f\u3001\u72ed\u5fc3\u75c7\u3092\u300cangina pectoris\u300d\u3068\u3057\u3066\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u6b69\u3044\u305f\u3068\u304d\u306a\u3069\u306b\u80f8\u304c\u82e6\u3057\u304f\u306a\u308a\u3001\u7acb\u3061\u6b62\u307e\u308b\u3068\u548c\u3089\u3050\u3002\u73fe\u5728\u3082\u3001\u72ed\u5fc3\u75c7\u3092\u7591\u3046\u969b\u306b\u5927\u5207\u306a\u75c7\u72b6\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">NEJM\u3067\u306f\u3001\u30d8\u30d0\u30fc\u30c7\u30f3\u304c\u75c7\u72b6\u3092\u8a73\u3057\u304f\u8a18\u8f09\u3059\u308b\u4e00\u65b9\u3001\u6cbb\u7642\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u63d0\u6848\u3067\u304d\u306a\u3044\u3068\u8ff0\u3079\u3066\u3044\u305f\u3053\u3068\u3082\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305a\u3001\u60a3\u8005\u3055\u3093\u306b\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u3092\u89b3\u5bdf\u3059\u308b\u3068\u3053\u308d\u304b\u3089\u3001\u75c5\u6c17\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u304d\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u540c\u305818\u4e16\u7d00\u306b\u306f\u3001\u82f1\u56fd\u306e\u5316\u5b66\u8005\u30b8\u30e7\u30bc\u30d5\u30fb\u30d7\u30ea\u30fc\u30b9\u30c8\u30ea\u30fc\uff08Joseph Priestley\uff09\u306b\u3088\u308bNO\u306e\u7814\u7a76\u3082\u884c\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u6642\u70b9\u3067\u306f\u3001\u72ed\u5fc3\u75c7\u3068\u3044\u3046\u75c5\u6c17\u3068NO\u3068\u3044\u3046\u6c17\u4f53\u306f\u3001\u5225\u3005\u306e\u7814\u7a76\u5bfe\u8c61\u3067\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u305d\u306e\u5f8c\u3001\u72ed\u5fc3\u75c7\u306b\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u304c\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u3055\u3089\u306b\u5f8c\u306e\u7814\u7a76\u3067NO\u3068\u306e\u95a2\u4fc2\u304c\u5206\u304b\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u81e8\u5e8a\u306e\u89b3\u5bdf\u3068\u5316\u5b66\u306e\u7814\u7a76\u304c\u7d50\u3073\u3064\u304f\u307e\u3067\u306b\u306f\u3001\u9577\u3044\u6642\u9593\u304c\u5fc5\u8981\u3067\u3057\u305f\u3002<\/p>\n<h2 id=\"nitro-sobrero\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">1840\u5e74\u4ee3\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u304c\u5408\u6210\u3055\u308c\u308b<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1840\u5e74\u4ee3\u3001\u30a4\u30bf\u30ea\u30a2\u306e\u5316\u5b66\u8005\u30a2\u30b9\u30ab\u30cb\u30aa\u30fb\u30bd\u30d6\u30ec\u30ed\uff08Ascanio Sobrero\uff09\u304c\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3092\u5408\u6210\u3057\u307e\u3057\u305f\u3002NEJM\u306e\u672c\u6587\u3067\u306f\u3001\u5408\u6210\u5e74\u30921846\u5e74\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u7206\u767a\u6027\u306e\u5f37\u3044\u7269\u8cea\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u4e00\u65b9\u3001\u30bd\u30d6\u30ec\u30ed\u306f\u81ea\u3089\u5408\u6210\u3057\u305f\u7269\u8cea\u3092\u3054\u304f\u5c11\u91cf\u820c\u306b\u89e6\u308c\u3055\u305b\u3001\u5f37\u3044\u982d\u75db\u3092\u7d4c\u9a13\u3057\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672a\u77e5\u306e\u5316\u5b66\u7269\u8cea\u3092\u53e3\u306b\u3059\u308b\u306e\u306f\u5371\u967a\u3067\u3059\u304c\u3001\u5f53\u6642\u306e\u8a18\u9332\u306b\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u4f53\u3078\u306e\u4f5c\u7528\u3082\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u3053\u306e\u6642\u70b9\u3067\u306f\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u304c\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u85ac\u306b\u306a\u308b\u3053\u3068\u3082\u3001\u305d\u306e\u4f5c\u7528\u306bNO\u304c\u95a2\u308f\u308b\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305a\u3001\u4eba\u306e\u4f53\u306b\u306f\u3063\u304d\u308a\u3057\u305f\u5909\u5316\u3092\u8d77\u3053\u3059\u7269\u8cea\u3068\u3057\u3066\u89b3\u5bdf\u3055\u308c\u3066\u3044\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n<h2 id=\"nitro-murrell\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u304c\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u3078<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">19\u4e16\u7d00\u5f8c\u534a\u306b\u306f\u3001\u8840\u7ba1\u3092\u5e83\u3052\u308b\u7269\u8cea\u304c\u5b9f\u969b\u306e\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u82f1\u56fd\u306e\u533b\u5e2b\u30c8\u30fc\u30de\u30b9\u30fb\u30ed\u30fc\u30c0\u30fc\u30fb\u30d6\u30e9\u30f3\u30c8\u30f3\uff08Thomas Lauder Brunton\uff09\u306f\u4e9c\u785d\u9178\u30a2\u30df\u30eb\u3092\u72ed\u5fc3\u75c7\u306b\u7528\u3044\u3001\u305d\u306e\u5f8c\u3001\u30a6\u30a3\u30ea\u30a2\u30e0\u30fb\u30de\u30ec\u30eb\uff08William Murrell\uff09\u304c\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u6cbb\u7642\u52b9\u679c\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30de\u30ec\u30eb\u306f1879\u5e74\u3001\u533b\u5b66\u8a8c <span lang=\"en\">Lancet<\/span> \u306b\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3092\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u306b\u7528\u3044\u305f\u5831\u544a\u3092\u767a\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u4e9c\u785d\u9178\u30a2\u30df\u30eb\u3068\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306f\u5225\u306e\u85ac\u3067\u3059\u304c\u3001\u8840\u7ba1\u3092\u5e83\u3052\u308b\u4f5c\u7528\u3092\u6cbb\u7642\u306b\u751f\u304b\u3059\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u3063\u305f\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e2\" href=\"#nitro-ref-2\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">2<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306f\u3001\u3053\u306e\u3088\u3046\u306b19\u4e16\u7d00\u306b\u306f\u3059\u3067\u306b\u72ed\u5fc3\u75c7\u306b\u4f7f\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u7d30\u80de\u306e\u4e2d\u3067\u3069\u306e\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u306e\u304b\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u306e\u306f\u300120\u4e16\u7d00\u5f8c\u534a\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u75c5\u6c17\u306e\u4ed5\u7d44\u307f\u3092\u3059\u3079\u3066\u89e3\u660e\u3057\u3066\u304b\u3089\u85ac\u304c\u4f5c\u3089\u308c\u305f\u306e\u3067\u306f\u306a\u304f\u3001\u5148\u306b\u6cbb\u7642\u52b9\u679c\u304c\u77e5\u3089\u308c\u3001\u305d\u306e\u7406\u7531\u3092\u5f8c\u306e\u7814\u7a76\u8005\u305f\u3061\u304c\u8abf\u3079\u3066\u3044\u3063\u305f\u3001\u3068\u3044\u3046\u9806\u756a\u3067\u3059\u3002<\/p>\n<h2 id=\"nitro-nobel\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u30a2\u30eb\u30d5\u30ec\u30c3\u30c9\u30fb\u30ce\u30fc\u30d9\u30eb\u3068\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u6b74\u53f2\u306b\u306f\u3001\u30a2\u30eb\u30d5\u30ec\u30c3\u30c9\u30fb\u30ce\u30fc\u30d9\u30eb\uff08Alfred Nobel\uff09\u3082\u767b\u5834\u3057\u307e\u3059\u3002\u30ce\u30fc\u30d9\u30eb\u306f\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3092\u5229\u7528\u3057\u305f\u30c0\u30a4\u30ca\u30de\u30a4\u30c8\u306e\u958b\u767a\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5f8c\u306b\u72ed\u5fc3\u75c7\u3092\u60a3\u3044\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306b\u3088\u308b\u6cbb\u7642\u3092\u52e7\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">NEJM\u3067\u306f\u3001\u30ce\u30fc\u30d9\u30eb\u304c\u3053\u306e\u5de1\u308a\u5408\u308f\u305b\u3092\u300c\u904b\u547d\u306e\u76ae\u8089\u300d\u3068\u8868\u73fe\u3057\u305f\u3053\u3068\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7206\u85ac\u3068\u3057\u3066\u5229\u7528\u3057\u3066\u304d\u305f\u7269\u8cea\u304c\u3001\u81ea\u5206\u306e\u5fc3\u81d3\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u52e7\u3081\u3089\u308c\u308b\u3002\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u5bfe\u7167\u7684\u306a\u4e8c\u3064\u306e\u7528\u9014\u304c\u5206\u304b\u308b\u30a8\u30d4\u30bd\u30fc\u30c9\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u305d\u3057\u3066\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u4f5c\u7528\u3092\u3081\u3050\u308b\u7814\u7a76\u306f\u3001\u5f8c\u306bNO\u306e\u50cd\u304d\u306e\u89e3\u660e\u3078\u9032\u307f\u3001\u4eca\u5ea6\u306f\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h2 id=\"nitro-murad\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u300c\u306a\u305c\u52b9\u304f\u306e\u304b\u300d\u3092\u3001\u7814\u7a76\u5ba4\u3067\u8abf\u3079\u308b<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">20\u4e16\u7d00\u306b\u5165\u308b\u3068\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u4f5c\u7528\u3092\u5b9f\u9a13\u5ba4\u3067\u8abf\u3079\u308b\u7814\u7a76\u304c\u9032\u307f\u307e\u3057\u305f\u3002\u8840\u7ba1\u306e\u7b4b\u8089\u3060\u3051\u3067\u306a\u304f\u3001\u6c17\u7ba1\u3084\u6d88\u5316\u7ba1\u306a\u3069\u306e\u5e73\u6ed1\u7b4b\u3082\u7de9\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3059\u3002\u5e73\u6ed1\u7b4b\u306f\u3001\u8840\u7ba1\u3084\u5185\u81d3\u306e\u58c1\u306a\u3069\u306b\u3042\u308b\u7b4b\u8089\u3067\u3059\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e3\" href=\"#nitro-ref-3\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">3<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u6cbb\u7642\u3067\u898b\u3089\u308c\u308b\u4f5c\u7528\u3092\u5b9f\u9a13\u3067\u3082\u78ba\u304b\u3081\u306a\u304c\u3089\u3001\u4f53\u306e\u4e2d\u306b\u3082\u3068\u3082\u3068\u3042\u308b\u4f55\u304b\u306e\u50cd\u304d\u3092\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u304c\u4ee3\u308f\u308a\u306b\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1977\u5e74\u3001\u30d5\u30a7\u30ea\u30c9\u30fb\u30e0\u30e9\u30c9\uff08Ferid Murad\uff09\u3089\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u785d\u9178\u85ac\u306e\u4f5c\u7528\u306bNO\u304c\u95a2\u308f\u308a\u3001\u7d30\u80de\u5185\u306ecGMP\u3068\u3044\u3046\u7269\u8cea\u3092\u4ecb\u3057\u3066\u8840\u7ba1\u306e\u7b4b\u8089\u304c\u7de9\u3080\u4ed5\u7d44\u307f\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u304d\u307e\u3059\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e3\" href=\"#nitro-ref-3\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">3<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u3053\u3053\u3067\u306f\u3001NO\u304c\u8840\u7ba1\u306e\u58c1\u306e\u7b4b\u8089\u306b\u300c\u7de9\u3093\u3067\u3088\u3044\u300d\u3068\u3044\u3046\u5408\u56f3\u3092\u4f1d\u3048\u308b\u3001\u3068\u8003\u3048\u308b\u3068\u5206\u304b\u308a\u3084\u3059\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306f\u3001\u3053\u306e\u5408\u56f3\u306b\u95a2\u4fc2\u3059\u308b\u4ed5\u7d44\u307f\u3092\u50cd\u304b\u305b\u3066\u8840\u7ba1\u3092\u5e83\u3052\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u85ac\u306e\u4f5c\u7528\u3092\u8aac\u660e\u3059\u308b\u624b\u304c\u304b\u308a\u304c\u5f97\u3089\u308c\u308b\u3068\u3001\u4eca\u5ea6\u306f\u3001\u4f53\u304c\u666e\u6bb5\u304b\u3089\u540c\u3058\u4ed5\u7d44\u307f\u3092\u4f7f\u3063\u3066\u3044\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u7591\u554f\u3082\u751f\u307e\u308c\u307e\u3059\u3002\u85ac\u3092\u6295\u4e0e\u3057\u305f\u3068\u304d\u3060\u3051\u50cd\u304f\u3082\u306e\u306a\u306e\u304b\u3002\u305d\u308c\u3068\u3082\u3001\u4f53\u81ea\u8eab\u306e\u8840\u7ba1\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u3082\u306e\u306a\u306e\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h2 id=\"nitro-endothelium\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u8840\u7ba1\u306e\u5185\u5074\u306b\u3042\u308b\u300c\u5185\u76ae\u300d\u306e\u5f79\u5272<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1980\u5e74\u3001\u30ed\u30d0\u30fc\u30c8\u30fb\u30d5\u30a1\u30fc\u30c1\u30b4\u30c3\u30c8\uff08Robert F. Furchgott\uff09\u3068\u30b8\u30e7\u30f3\u30fb\u30b6\u30ef\u30ba\u30ad\u30fc\uff08John V. Zawadzki\uff09\u304c\u3001\u8840\u7ba1\u5185\u76ae\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092 <span lang=\"en\">Nature<\/span> \u306b\u767a\u8868\u3057\u307e\u3057\u305f\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e4\" href=\"#nitro-ref-4\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">4<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u53d6\u308a\u51fa\u3057\u305f\u8840\u7ba1\u306b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u3068\u3044\u3046\u7269\u8cea\u3092\u52a0\u3048\u308b\u3068\u3001\u8840\u7ba1\u304c\u7de9\u3080\u5834\u5408\u3068\u3001\u305d\u3046\u306a\u3089\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u9055\u3044\u3092\u8abf\u3079\u308b\u3068\u3001\u6a19\u672c\u3092\u6e96\u5099\u3059\u308b\u969b\u306b\u8840\u7ba1\u306e\u5185\u5074\u3092\u3053\u3059\u3063\u3066\u3057\u307e\u3063\u305f\u304b\u3069\u3046\u304b\u304c\u95a2\u308f\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u5185\u5074\u306e\u8584\u3044\u7d30\u80de\u306e\u5c64\u3092\u6b8b\u3059\u3068\u8840\u7ba1\u306f\u7de9\u307f\u3001\u305d\u306e\u5c64\u304c\u53d6\u308a\u9664\u304b\u308c\u308b\u3068\u3001\u540c\u3058\u53cd\u5fdc\u304c\u8d77\u3053\u3089\u306a\u304f\u306a\u308b\u3002\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306b\u3088\u308b\u5f1b\u7de9\u306b\u306f\u3001\u8840\u7ba1\u306e\u7b4b\u8089\u3060\u3051\u3067\u306a\u304f\u3001\u8840\u7ba1\u5185\u76ae\u304c\u5fc5\u8981\u3060\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u305d\u3053\u3067\u3001\u5185\u76ae\u304b\u3089\u300c\u8840\u7ba1\u306e\u7b4b\u8089\u3092\u7de9\u3081\u308b\u4f55\u304b\u300d\u304c\u51fa\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7269\u8cea\u306f\u3001EDRF\uff08endothelium-derived relaxing factor\uff1a\u5185\u76ae\u7531\u6765\u5f1b\u7de9\u56e0\u5b50\uff09\u3068\u547c\u3070\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u9577\u3044\u540d\u524d\u3067\u3059\u304c\u3001\u610f\u5473\u306f\u300c\u8840\u7ba1\u306e\u5185\u5074\u306e\u7d30\u80de\u304b\u3089\u51fa\u3066\u3001\u8840\u7ba1\u3092\u7de9\u3081\u308b\u3082\u306e\u300d\u3067\u3059\u3002\u6b63\u4f53\u306f\u307e\u3060\u5206\u304b\u3089\u306a\u3044\u305f\u3081\u3001\u307e\u305a\u3001\u305d\u306e\u50cd\u304d\u3092\u8868\u3059\u540d\u524d\u304c\u3064\u3051\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<h2 id=\"nitro-coronary\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u57fa\u790e\u7814\u7a76\u304b\u3089\u3001\u518d\u3073\u60a3\u8005\u3055\u3093\u306e\u51a0\u52d5\u8108\u3078<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1986\u5e74\u3001NEJM\u306b\u63b2\u8f09\u3055\u308c\u305f\u30e9\u30c9\u30de\u30fc\uff08P. L. Ludmer\uff09\u3089\u306e\u7814\u7a76\u3067\u306f\u3001\u60a3\u8005\u3055\u3093\u306e\u51a0\u52d5\u8108\u306b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u3092\u6295\u4e0e\u3057\u3001\u305d\u306e\u53cd\u5fdc\u3092\u8abf\u3079\u307e\u3057\u305f\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e5\" href=\"#nitro-ref-5\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">5<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u6b63\u5e38\u306a\u51a0\u52d5\u8108\u3067\u306f\u8840\u7ba1\u304c\u5e83\u304c\u308b\u4e00\u65b9\u3001\u52d5\u8108\u786c\u5316\u306e\u3042\u308b\u51a0\u52d5\u8108\u3067\u306f\u3001\u9006\u306b\u7e2e\u3080\u53cd\u5fdc\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u5f37\u3044\u72ed\u7a84\u304c\u3042\u308b\u8840\u7ba1\u3060\u3051\u3067\u306a\u304f\u3001\u8efd\u5ea6\u306e\u52d5\u8108\u786c\u5316\u3067\u3082\u3001\u3053\u306e\u53cd\u5fdc\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u3068\u3053\u308d\u304c\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u8abf\u3079\u305f\u3059\u3079\u3066\u306e\u8840\u7ba1\u304c\u5e83\u304c\u308a\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">18\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5c0f\u898f\u6a21\u306a\u7814\u7a76\u3067\u3059\u304c\u3001\u8840\u7ba1\u306b\u306f\u300c\u3069\u308c\u304f\u3089\u3044\u72ed\u304f\u306a\u3063\u3066\u3044\u308b\u304b\u300d\u3068\u3044\u3046\u5f62\u306e\u554f\u984c\u306b\u52a0\u3048\u3001\u300c\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u9069\u5207\u306b\u5e83\u304c\u308c\u308b\u304b\u300d\u3068\u3044\u3046\u50cd\u304d\u306e\u554f\u984c\u3082\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u5b9f\u9a13\u5ba4\u3067\u8abf\u3079\u3089\u308c\u3066\u3044\u305f\u5185\u76ae\u306e\u50cd\u304d\u304c\u3001\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u306e\u51a0\u52d5\u8108\u306e\u7570\u5e38\u3092\u7406\u89e3\u3059\u308b\u624b\u304c\u304b\u308a\u306b\u3082\u306a\u3063\u3066\u3044\u304d\u307e\u3057\u305f\u3002<\/p>\n<h2 id=\"nitro-no\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">EDRF\u306e\u6b63\u4f53\u306fNO\u3060\u3063\u305f<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1987\u5e74\u3001\u30b5\u30eb\u30d0\u30c9\u30fc\u30eb\u30fb\u30e2\u30f3\u30ab\u30c0\uff08Salvador Moncada\uff09\u3089\u3068\u3001\u30eb\u30a4\u30fb\u30a4\u30b0\u30ca\u30ed\uff08Louis J. Ignarro\uff09\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u305d\u308c\u305e\u308cEDRF\u306e\u6b63\u4f53\u3092NO\u3068\u7d50\u3073\u3064\u3051\u308b\u7814\u7a76\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e6\" href=\"#nitro-ref-6\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">6<\/a>,<a aria-label=\"\u53c2\u8003\u6587\u732e7\" href=\"#nitro-ref-7\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">7<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u8840\u7ba1\u5185\u76ae\u304c\u51fa\u3057\u3066\u3044\u305f\u300c\u8840\u7ba1\u3092\u7de9\u3081\u308b\u4f55\u304b\u300d\u306f\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u306e\u4f5c\u7528\u3092\u8abf\u3079\u308b\u4e2d\u3067\u3082\u91cd\u8981\u3060\u3063\u305f\u3001\u4e00\u9178\u5316\u7a92\u7d20\u3060\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u5916\u304b\u3089\u6295\u4e0e\u3057\u305f\u85ac\u306e\u4f5c\u7528\u3092\u8abf\u3079\u308b\u7814\u7a76\u3068\u3001\u4f53\u304c\u3082\u3068\u3082\u3068\u6301\u3063\u3066\u3044\u308b\u8840\u7ba1\u8abf\u7bc0\u306e\u4ed5\u7d44\u307f\u3092\u8abf\u3079\u308b\u7814\u7a76\u304c\u3001\u3053\u3053\u3067\u3064\u306a\u304c\u308a\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u8840\u7ba1\u306f\u3001\u8840\u6db2\u304c\u901a\u308b\u3060\u3051\u306e\u7ba1\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5185\u5074\u306e\u7d30\u80de\u304c\u5408\u56f3\u3092\u9001\u308a\u3001\u5468\u56f2\u306e\u7b4b\u8089\u306e\u7dca\u5f35\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\u3002\u85ac\u306e\u4ed5\u7d44\u307f\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u3001\u4eba\u9593\u306e\u8840\u7ba1\u304c\u666e\u6bb5\u3069\u3046\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306b\u3082\u3064\u306a\u304c\u3063\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1992\u5e74\u306b\u306f\u3001\u8840\u7ba1\u5185\u76ae\u3067NO\u3092\u4f5c\u308b\u9175\u7d20\u3001eNOS\uff08\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff09\u306e\u907a\u4f1d\u5b50\u304c\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u307e\u3057\u305f\u3002\u5185\u76ae\u304b\u3089\u51fa\u308b\u5408\u56f3\u306e\u6b63\u4f53\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u4f5c\u3089\u308c\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u304d\u307e\u3059\u3002<\/p>\n<h2 id=\"nitro-prize\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">1998\u5e74\u3001NO\u7814\u7a76\u306b\u30ce\u30fc\u30d9\u30eb\u8cde<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">1998\u5e74\u3001\u30d5\u30a1\u30fc\u30c1\u30b4\u30c3\u30c8\u3001\u30a4\u30b0\u30ca\u30ed\u3001\u30e0\u30e9\u30c9\u306e3\u4eba\u306b\u3001\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u304c\u6388\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u53d7\u8cde\u7406\u7531\u306f\u3001NO\u304c\u5fc3\u8840\u7ba1\u7cfb\u306e\u60c5\u5831\u4f1d\u9054\u306b\u50cd\u304f\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u767a\u898b\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u305d\u306e\u3082\u306e\u306e\u767a\u660e\u304c\u53d7\u8cde\u3057\u305f\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u53e4\u304f\u304b\u3089\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u3066\u3044\u305f\u85ac\u306e\u4f5c\u7528\u3068\u3001\u4f53\u81ea\u8eab\u304c\u6301\u3064\u8840\u7ba1\u8abf\u7bc0\u306e\u4ed5\u7d44\u307f\u3092\u7d50\u3073\u3064\u3051\u305f\u7814\u7a76\u304c\u3001\u5927\u304d\u304f\u8a55\u4fa1\u3055\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30ce\u30fc\u30d9\u30eb\u304c\u7206\u85ac\u306b\u5229\u7528\u3057\u3001\u81ea\u8eab\u306e\u6cbb\u7642\u306b\u3082\u52e7\u3081\u3089\u308c\u305f\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3002\u305d\u306e\u4f5c\u7528\u306b\u95a2\u308f\u308b\u4f53\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u304c\u3001\u5f8c\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u306b\u3064\u306a\u304c\u308a\u307e\u3057\u305f\u3002<\/p>\n<h2 id=\"nitro-sildenafil\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">bench to bedside to bedroom<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">NO\u306b\u3088\u308b\u60c5\u5831\u4f1d\u9054\u3078\u306e\u7406\u89e3\u306f\u3001\u65b0\u3057\u3044\u85ac\u306e\u958b\u767a\u306b\u3082\u3064\u306a\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u305d\u306e\u4e00\u3064\u304c\u3001\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u3067\u3059\u3002\u73fe\u5728\u3067\u306f\u52c3\u8d77\u4e0d\u5168\u6cbb\u7642\u85ac\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3082\u3068\u3082\u3068\u306f\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u85ac\u3092\u76ee\u6307\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u306f\u3001NO\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u8840\u7ba1\u62e1\u5f35\u306e\u5408\u56f3\u3092\u9577\u304f\u4fdd\u3064\u65b9\u5411\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002\u72ed\u5fc3\u75c7\u306e\u85ac\u3068\u3057\u3066\u306e\u958b\u767a\u304b\u3089\u306f\u65b9\u5411\u304c\u5909\u308f\u308a\u3001\u52c3\u8d77\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u78ba\u304b\u3081\u3089\u308c\u307e\u3057\u305f\u30021998\u5e74\u306b\u306f\u3001\u305d\u306e\u81e8\u5e8a\u8a66\u9a13\u304cNEJM\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <span class=\"nitro-citation\" style=\"font-family:inherit;font-size:inherit;font-weight:400;white-space:nowrap;color:inherit;\">(<a aria-label=\"\u53c2\u8003\u6587\u732e8\" href=\"#nitro-ref-8\" style=\"color:inherit;text-decoration:none;font-family:inherit;\">8<\/a>)<\/span><\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u533b\u5b66\u3067\u306f\u3001\u7814\u7a76\u5ba4\u3067\u306e\u767a\u898b\u3092\u60a3\u8005\u3055\u3093\u306e\u6cbb\u7642\u3078\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u300cbench to bedside\u300d\u3068\u8868\u73fe\u3057\u307e\u3059\u3002bench\u306f\u5b9f\u9a13\u53f0\u3001bedside\u306f\u60a3\u8005\u3055\u3093\u306e\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u3067\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u4eca\u56de\u306eNEJM\u306e\u8457\u8005\u305f\u3061\u306f\u3001\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u306e\u7d4c\u7def\u3092\u3001\u6b21\u306e\u3088\u3046\u306b\u8868\u73fe\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\"><span lang=\"en\">bench to bedside to bedroom<\/span><\/p><p style=\"margin:0 0 1.25em;font-weight:400;\">\u7814\u7a76\u5ba4\u304b\u3089\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u3078\u3001\u305d\u3057\u3066\u30d9\u30c3\u30c9\u30eb\u30fc\u30e0\u3078\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u72ed\u5fc3\u75c7\u306e\u85ac\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u304c\u3001\u52c3\u8d77\u4e0d\u5168\u306e\u6cbb\u7642\u306b\u3064\u306a\u304c\u3063\u305f\u3002\u305d\u306e\u7d4c\u7def\u3092\u8868\u3057\u305f\u4e00\u7bc0\u3067\u3059\u3002\u306a\u304a\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u305d\u306e\u3082\u306e\u304c\u52c3\u8d77\u4e0d\u5168\u6cbb\u7642\u85ac\u306b\u306a\u3063\u305f\u308f\u3051\u3067\u306f\u306a\u304f\u3001NO\u306b\u95a2\u308f\u308b\u4ed5\u7d44\u307f\u3078\u306e\u7406\u89e3\u304c\u3001\u5225\u306e\u85ac\u306e\u958b\u767a\u3084\u4f7f\u3044\u9053\u306b\u3064\u306a\u304c\u3063\u305f\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h2 id=\"nitro-return\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u304b\u3089\u3001\u518d\u3073\u7814\u7a76\u5ba4\u3078<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u8ad6\u6587\u306e\u6700\u5f8c\u3067\u306f\u3001\u7814\u7a76\u5ba4\u304b\u3089\u81e8\u5e8a\u3078\u3068\u3044\u3046\u65b9\u5411\u3060\u3051\u3067\u306a\u304f\u3001\u60a3\u8005\u3055\u3093\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3053\u3068\u304c\u3001\u65b0\u305f\u306a\u7814\u7a76\u306e\u554f\u3044\u3068\u3057\u3066\u7814\u7a76\u5ba4\u3078\u623b\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u304c\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\"><span lang=\"en\">from the bedside back to the bench<\/span><\/p><p style=\"margin:0 0 1.25em;font-weight:400;\">\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u304b\u3089\u3001\u518d\u3073\u7814\u7a76\u5ba4\u3078\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u3053\u306e\u6b74\u53f2\u3067\u306f\u3001\u60a3\u8005\u3055\u3093\u306e\u75c7\u72b6\u3092\u89b3\u5bdf\u3057\u3001\u85ac\u3067\u8d77\u304d\u305f\u5909\u5316\u3092\u78ba\u304b\u3081\u3001\u305d\u306e\u7406\u7531\u3092\u7814\u7a76\u5ba4\u3067\u8abf\u3079\u3001\u65b0\u3057\u304f\u5206\u304b\u3063\u305f\u4ed5\u7d44\u307f\u3092\u307e\u305f\u6cbb\u7642\u3078\u3064\u306a\u3052\u308b\u3001\u3068\u3044\u3046\u5f80\u5fa9\u304c\u7e70\u308a\u8fd4\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u500b\u4eba\u7684\u306b\u3082\u3001\u533b\u5b66\u306f\u7814\u7a76\u5ba4\u3067\u751f\u307e\u308c\u305f\u3082\u306e\u304c\u4e00\u65b9\u7684\u306b\u8a3a\u7642\u3078\u4f1d\u308f\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u65e5\u3005\u306e\u8a3a\u7642\u3067\u751f\u307e\u308c\u305f\u7591\u554f\u304c\u7814\u7a76\u3078\u623b\u308a\u3001\u305d\u306e\u7b54\u3048\u304c\u65b0\u3057\u3044\u8a3a\u7642\u306b\u3064\u306a\u304c\u308b\u3001\u3068\u3044\u3046\u3084\u308a\u3068\u308a\u306e\u4e2d\u3067\u767a\u5c55\u3057\u3066\u304d\u305f\u306e\u3060\u3068\u611f\u3058\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3068NO\u306e\u6b74\u53f2\u3092\u632f\u308a\u8fd4\u308b\u3068\u3001\u73fe\u5728\u306e\u6cbb\u7642\u306e\u80cc\u666f\u306b\u3001\u3053\u3046\u3057\u305f\u7a4d\u307f\u91cd\u306d\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u540c\u3058\u4e3b\u984c\u306b\u623b\u308a\u306a\u304c\u3089\u3082\u3001\u305d\u306e\u305f\u3073\u306b\u7406\u89e3\u304c\u6df1\u307e\u3063\u3066\u3044\u304f\u3002\u81e8\u5e8a\u3068\u7814\u7a76\u306e\u5f80\u5fa9\u3092\u91cd\u306d\u3066\u533b\u5b66\u304c\u767a\u5c55\u3057\u3066\u304d\u305f\u3053\u3068\u3092\u3001\u3042\u3089\u305f\u3081\u3066\u611f\u6168\u6df1\u304f\u611f\u3058\u307e\u3059\u3002<\/p>\n<h2 id=\"nitro-closing\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u6700\u5f8c\u306b<\/h2>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u3067\u73fe\u5728\u3082\u4f7f\u308f\u308c\u3066\u3044\u308b\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3002\u305d\u306e\u80cc\u666f\u306b\u306f\u300118\u4e16\u7d00\u306e\u81e8\u5e8a\u89b3\u5bdf\u300119\u4e16\u7d00\u306e\u5316\u5b66\u3001\u8840\u7ba1\u5185\u76ae\u3068NO\u306e\u7814\u7a76\u3001\u305d\u3057\u3066\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u3078\u3068\u7d9a\u304f\u7d4c\u7def\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u666e\u6bb5\u4f7f\u3063\u3066\u3044\u308b\u85ac\u306b\u3064\u3044\u3066\u5c11\u3057\u6b74\u53f2\u3092\u3055\u304b\u306e\u307c\u308b\u3068\u3001\u73fe\u5728\u306e\u6cbb\u7642\u304c\u3069\u306e\u3088\u3046\u306b\u5f62\u3065\u304f\u3089\u308c\u3066\u304d\u305f\u306e\u304b\u304c\u898b\u3048\u3066\u304d\u307e\u3059\u3002<\/p>\n<p style=\"margin:0 0 1.25em;font-weight:400;\">\u5f53\u9662\u3067\u306f\u3001\u80f8\u75db\u3084\u80f8\u306e\u5727\u8feb\u611f\u3001\u6b69\u3044\u305f\u3068\u304d\u306e\u80f8\u90e8\u4e0d\u5feb\u611f\u306a\u3069\u3001\u72ed\u5fc3\u75c7\u304c\u7591\u308f\u308c\u308b\u75c7\u72b6\u306b\u3064\u3044\u3066\u3082\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u3002\u6c17\u306b\u306a\u308b\u75c7\u72b6\u304c\u3042\u308a\u307e\u3057\u305f\u3089\u3001\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p class=\"nitro-safety\" style=\"margin:1.5em 0 0;font-family:inherit;font-size:0.86em;line-height:1.85;font-weight:400;color:#5d686d;\">\u5f37\u3044\u80f8\u75db\u304c\u7d9a\u304f\u5834\u5408\u3084\u3001\u51b7\u6c57\u30fb\u5f37\u3044\u606f\u82e6\u3057\u3055\u306a\u3069\u3092\u4f34\u3046\u5834\u5408\u306f\u3001\u901a\u5e38\u306e\u5916\u6765\u53d7\u8a3a\u3092\u5f85\u305f\u305a\u3001119\u756a\u3067\u6551\u6025\u8981\u8acb\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2 id=\"nitro-references\" style=\"margin:2.3em 0 1em;padding:0 0 0.55em;border:0;border-bottom:1px solid #dde6e3;background:transparent;color:#285761;font-family:inherit;font-size:1.3em;line-height:1.65;font-weight:600;box-shadow:none;\">\u53c2\u8003\u6587\u732e<\/h2>\n<p style=\"font-size:0.85em;color:#657278;margin:0 0 1em;\">\u672c\u6587\u4e2d\u3067\u7d39\u4ecb\u3057\u305f\u95a2\u9023\u7814\u7a76\u3067\u3059\u3002\u30d9\u30fc\u30b9\u3068\u306a\u308bNEJM\u306e\u8ad6\u6587\u306f\u3001\u5192\u982d\u306b\u63b2\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<ol class=\"nitro-references\" start=\"2\" style=\"margin:0;padding-left:1.6em;font-family:inherit;font-size:inherit;line-height:1.8;font-weight:400;color:inherit;\">\n<li id=\"nitro-ref-2\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"2\">Murrell W. Nitro-glycerine as a remedy for angina pectoris. Lancet. 1879;1:80\u201381,113\u2013115,151\u2013152,225\u2013227. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(02)46032-1\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u539f\u8457<\/a><\/li>\n<li id=\"nitro-ref-3\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"3\">Murad F. Shattuck Lecture \u2014 Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med. 2006;355:2003\u20132011. doi:10.1056\/NEJMsa063904. <a href=\"https:\/\/doi.org\/10.1056\/NEJMsa063904\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u8b1b\u6f14\u8ad6\u6587<\/a><\/li>\n<li id=\"nitro-ref-4\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"4\">Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373\u2013376. doi:10.1038\/288373a0. <a href=\"https:\/\/doi.org\/10.1038\/288373a0\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u539f\u8457<\/a><\/li>\n<li id=\"nitro-ref-5\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"5\">Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046\u20131051. doi:10.1056\/NEJM198610233151702. <a href=\"https:\/\/doi.org\/10.1056\/NEJM198610233151702\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u539f\u8457<\/a><\/li>\n<li id=\"nitro-ref-6\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"6\">Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524\u2013526. doi:10.1038\/327524a0. <a href=\"https:\/\/doi.org\/10.1038\/327524a0\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u539f\u8457<\/a><\/li>\n<li id=\"nitro-ref-7\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"7\">Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987;84:9265\u20139269. doi:10.1073\/pnas.84.24.9265. <a href=\"https:\/\/doi.org\/10.1073\/pnas.84.24.9265\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" target=\"_blank\">\u539f\u8457<\/a><\/li>\n<li id=\"nitro-ref-8\" style=\"margin:0 0 1.15em;padding-left:0.25em;font-family:inherit;\" value=\"8\">Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA; Sildenafil Study Group. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 1998;338:1397\u20131404. doi:10.1056\/NEJM199805143382001. <a href=\"https:\/\/doi.org\/10.1056\/NEJM199805143382001\" rel=\"noopener noreferrer\" style=\"color:inherit;text-decoration:underline;font-family:inherit;font-size:inherit;\" 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